Alnylam Reports 76% Increase in Product Sales in the Fourth Quarter and Expects Product Sales of Up to $1 Billion in Fiscal Year 2022

Alnylam Pharmaceuticals Inc. ALNY Fourth-quarter product revenue increased 76% year-over-year to $198.5 million, primarily due to the continued global expansion of Onpattro and Givlaari, and sales of a third commercial product, Oxlumo.

  • Sales of collaborations increased by 18%, mainly due to increased revenue from collaboration agreements with Regeneron Pharmaceuticals Inc. REGN and Novartis AG NVS.
  • Total sales rose from $163.5 million to $258.5 million, beating the consensus of $233.62 million.
  • The company posted an adjusted EPS loss of ($1.69), missing the consensus of $(1.54) from $(1.60) a year ago.
  • Onpattro (patisiran) achieved sales of $139 million, +53.4% ​​Y/Y, and reached more than 2,050 patients worldwide on commercial Onpattro therapy as of December 31, 2021.
  • Givlaari (givosiran) posted revenue of $40.69 million in the fourth quarter, up 83.7%. The company has reached over 350 patients worldwide on commercial Givlaari treatment.
  • Sales of Oxlumo (lumasiran) reached $19.2 million. Reaches over 140 patients worldwide on commercial Oxlumo treatment.
  • Advice: Alnylam forecasts FY22 product sales of $900-1 billion, with collaborations and royalty sales of $175-225 million.
  • Price Action: Shares of ALNY were up 2.13% at $154.62 during Thursday’s last check trading session.


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